A holiday donation from the Shapiro family!

We are so thrilled that the Shapiro family decided to make a donation to the 401 Project in lieu of sending out Holiday Cards. What a great idea! Thank you!

From Shirley Shapiro: 

This year, instead of mailing out holiday cards, we decided to use the money we would have spent on cards and postage and make a donation to a charity that is near and dear to our hearts.http://www.401project.com/bo-spangler
We hope that your holidays are filled with love and laughter. Love, Justin, Shirley, Audrey and Joe

Donate for free while you shop online to cure MECP2! Join us at iGive.com

It is so easy to donate for free while you shop online. Please join us in donating to cure MECP2 Duplication Syndrome by visiting iGive.com and selecting "Rett Syndrome Research Trust (MECP2 Fund)" as your cause. We've been using it now for months on our everyday purchases, and the totals are adding up! 

We've found the easiest thing to do is install the iGive button, and then when you visit a website, you click on the button to donate a portion of your purchase to cure MECP2. 

If you have questions, please feel free to contact us at info@401project.com for help.

Breaking News - MECP2 Duplication Syndrome is Reversible (Updated to include Spanish translation)

In a Nature article published online today, November 25, 2015, it was revealed that researchers at the Baylor College of Medicine, led by Dr. Huda Y. Zoghbi, have reversed MECP2 Duplication Syndrome in adult symptomatic mice using antisense oligonucleotide (ASO) gene therapy. In this landmark letter to Nature, mice treated with an experimental ASO administered through the central nervous system experienced the reduction of MECP2 protein to normal levels. Many impressive results were observed. Several behavioral tests were conducted, and in all cases, symptoms of hypoactivity, anxiety, and abnormal social behavior were resolved. Additionally, the seizure activity of the mice and abnormal EEG discharges were abolished. Lastly, initial studies demonstrated that reducing the MECP2 protein levels to the correct amount also normalized the expression of the other genes controlled by the MECP2 protein. Excitingly, the ASO was also administered to lymphoblastoid cells from MECP2 Duplication Syndrome patients, and MECP2 mRNA levels were restored to the correct concentration in these cells. 

The Reverse MECP2 NYC Gala hosted by Reverse Rett NYC was a huge success!

The Reverse MECP2 NYC charity gala hosted by Reverse Rett NYC was a great success. Nearly $20K was raised for research to cure MECP2 Duplication Syndrome. Mr. Ryan and Dr. Kimberly Spangler, parents of Bo Spangler, MECP2-affected boy, spearheaded this first U.S.-based fundraising charity gala. Attendees traveled from as far as San Francisco (much love to our 401 Project team member, Dyna Mendoza!) to partake in the cocktail event. 

We are actively looking for sponsors for our Cure MECP2 Bucks County event in September 2016. Contact us for details (info@401project.com). 

Are you interested in hosting a dinner party or charity gala? Please reach out to us and let us know so we can help.